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Kalivas, Peter
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overview The Kalivas lab studies neuroplasticity underlying the development of addiction to drugs of abuse, as well as the learning and memory deficits associated with impoverished rearing environments. Research is at the level of protein biochemistry, neural circuitry and behavioral modeling. The current focus for both addiction and isolation rearing is in adaptations in excitatory neurotransmission. In collaboration with electrophysiologists in the department (Drs Lavin, Seamans, Woodward) we are elucidating the fundamental role of extracellular glutamate homeostatis in regulating neurotransmission and neuroplasticity. This has led to preclinical and clinical evaluations of specific proteins as targets in treating addiction, including metabotropic glutamate receptors and the cystine-glutamate exchanger. Brain circuitry underlying addiction: Long-term cellular changes in the glutamate neurons projecting from the prefrontal cortex to the basal ganglia are critical mediators of addictive behaviors. This includes changes in glutamate homeostasis and G-protein signaling, and involves proteins such as Homer, xCT, AGS3 and mGluRs.
One or more keywords matched the following items that are connected to Kalivas, Peter
Item TypeName
Academic Article Neuroadaptations involved in amphetamine and cocaine addiction.
Academic Article Neuroadaptations in ionotropic and metabotropic glutamate receptor mRNA produced by cocaine treatment.
Academic Article Ibotenic acid lesions of the dorsal prefrontal cortex disrupt the expression of behavioral sensitization to cocaine.
Academic Article Glutamatergic and dopaminergic afferents to the prefrontal cortex regulate spatial working memory in rats.
Academic Article Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior.
Academic Article Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse.
Academic Article Prefrontal group II metabotropic glutamate receptor activation decreases performance on a working memory task.
Academic Article Metabotropic glutamate receptor regulation of extracellular glutamate levels in the prefrontal cortex.
Academic Article Cystine/glutamate antiporter regulation of vesicular glutamate release.
Academic Article Impoverished rearing environment alters metabotropic glutamate receptor expression and function in the prefrontal cortex.
Academic Article Regulation of extracellular glutamate in the prefrontal cortex: focus on the cystine glutamate exchanger and group I metabotropic glutamate receptors.
Academic Article Activation of orbital and medial prefrontal cortex by methylphenidate in cocaine-addicted subjects but not in controls: relevance to addiction.
Academic Article The neural basis of addiction: a pathology of motivation and choice.
Academic Article Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats.
Academic Article Addiction as a pathology in prefrontal cortical regulation of corticostriatal habit circuitry.
Academic Article The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior.
Academic Article A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens.
Academic Article The glutamate homeostasis hypothesis of addiction.
Academic Article Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion.
Academic Article Role of the prefrontal cortex and nucleus accumbens in reinstating methamphetamine seeking.
Academic Article Neuroadaptive changes in NMDAR1 gene expression after extinction of cocaine self-administration.
Academic Article Heroin relapse requires long-term potentiation-like plasticity mediated by NMDA2b-containing receptors.
Academic Article Optogenetic inhibition of cocaine seeking in rats.
Academic Article Stress-induced sensitization to cocaine: actin cytoskeleton remodeling within mesocorticolimbic nuclei.
Academic Article Forebrain astroglial plasticity is induced following withdrawal from repeated cocaine administration.
Academic Article Effects of cocaine and footshock stress on extracellular dopamine levels in the medial prefrontal cortex.
Academic Article Chronic haloperidol does not alter G protein alpha-subunit levels in rats.
Academic Article Repeated daily cocaine alters subsequent cocaine-induced increase of extracellular dopamine in the medial prefrontal cortex.
Academic Article Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior.
Academic Article Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission.
Academic Article Cystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking.
Academic Article Distinct roles for different Homer1 isoforms in behaviors and associated prefrontal cortex function.
Academic Article Long-term neuroadaptations produced by withdrawal from repeated cocaine treatment: role of dopaminergic receptors in modulating cortical excitability.
Academic Article Opposing roles for the ventral prefrontal cortex and the basolateral amygdala on the spontaneous recovery of cocaine-seeking in rats.
Academic Article The glutamatergic projection from the prefrontal cortex to the nucleus accumbens core is required for cocaine-induced decreases in ventral pallidal GABA.
Academic Article The role of cystine-glutamate exchange in nicotine dependence in rats and humans.
Academic Article N-Acetylcysteine reverses cocaine-induced metaplasticity.
Academic Article Extinction circuits for fear and addiction overlap in prefrontal cortex.
Academic Article Extinction training after cocaine self-administration induces glutamatergic plasticity to inhibit cocaine seeking.
Academic Article Reversing cocaine-induced synaptic potentiation provides enduring protection from relapse.
Academic Article New medications for drug addiction hiding in glutamatergic neuroplasticity.
Academic Article The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine.
Academic Article Reduced LTP and LTD in prefrontal cortex synapses in the nucleus accumbens after heroin self-administration.
Academic Article Interactions between dopamine and excitatory amino acids in behavioral sensitization to psychostimulants.
Academic Article Individual locomotor response to novelty predicts selective alterations in D1 and D2 receptors and mRNAs.
Concept Prefrontal Cortex
Academic Article Prelimbic cortex and ventral tegmental area modulate synaptic plasticity differentially in nucleus accumbens during cocaine-reinstated drug seeking.
Academic Article The good and bad news about glutamate in drug addiction.
Academic Article Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior.
Academic Article Chemogenetic Activation of an Extinction Neural Circuit Reduces Cue-Induced Reinstatement of Cocaine Seeking.
Academic Article Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.
Academic Article Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking.
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  • Prefrontal Cortex